Avanafil: A Detailed Review of the Drug
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1. Avanafil: A Detailed Review of the Drug
  1. General Information
Avanafil is a drug that belongs to the group of phosphodiesterase type 5 (PDE5) inhibitors- https://viagra-withoutadoctorprescriptions.com/comprar-avana-spain.html. It is used to treat erectile dysfunction (ED) in men. The active substance, avanafil, helps to relax the smooth muscles of the vessels of the penis, improving blood flow and providing a stable erection with sexual stimulation.

2. Mechanism of Action
Avanafil blocks the enzyme phosphodiesterase type 5, which destroys cyclic guanosine monophosphate (cGMP). cGMP is a substance responsible for relaxing smooth muscles and dilating blood vessels in the penis. During sexual stimulation, nitric oxide (NO) is released, which activates the production of cGMP. Avanafil enhances this process by providing blood flow to the cavernous bodies of the penis and promoting erection.

3. Indications for use
Avanafil is prescribed for the treatment of erectile dysfunction of various origins:

Psychogenic ED (stress, anxiety, depression).
Organic ED (vascular disorders, diabetes, hormonal disorders).
Mixed ED (combination of psychogenic and organic causes).

4. Release forms and dosage
Avanafil is available in the form of tablets for oral use. Standard dosages: 50 mg, 100 mg and 200 mg.

The initial recommended dose is 100 mg, taken 15-30 minutes before planned sexual activity.

Depending on effectiveness and tolerability, the dose can be increased to 200 mg or decreased to 50 mg.

The drug is taken no more than once a day.

5. Effectiveness
Avanafil starts to work 15-30 minutes after taking it, and its effect lasts up to 6 hours. This makes the drug convenient for spontaneous intimacy. Compared to other PDE5 inhibitors (for example, sildenafil or tadalafil), avanafil has a faster onset of action and fewer side effects.

6. Side effects
Like any drug, avanafil can cause side effects, although they are usually mild and temporary. The most common are:

Headache.
Flushed face.
Nasal congestion.
Dizziness.
Upset stomach.
Back pain.
In rare cases, more serious side effects are possible, such as blurred vision, low blood pressure, or priapism (prolonged and painful erection). If such symptoms occur, you should immediately consult a doctor.

7. Contraindications
Avanafil is contraindicated in the following cases:

Allergy to avanafil or other components of the drug.

Take nitrates (eg, nitroglycerin) or nitric oxide donors.

Severe cardiovascular diseases (unstable angina, heart failure).

Recent stroke or myocardial infarction.

Severe liver or kidney disease.

Age under 18.

8. Interaction with other drugs
Avanafil can interact with other drugs, so it is important to tell your doctor about all the drugs you are taking. Avanafil should be used with particular caution with:

Nitrates (risk of a sharp drop in blood pressure).

Alpha-blockers (hypertensive effect).

CYP3A4 inhibitors (eg, ketoconazole, ritonavir), which may increase avanafil blood concentrations.

CYP3A4 inducers (eg, rifampicin), which may reduce the effectiveness of avanafil.

9. Special instructions

Avanafil does not protect against sexually transmitted infections (STIs), so barrier methods of contraception should be used if necessary.

The drug is not a libido stimulant and only works with sexual stimulation.

Before starting to take avanafil, it is recommended to consult a doctor, especially if you have chronic diseases.

10. Conclusion
Avanafil is an effective and safe drug for the treatment of erectile dysfunction. Its advantages include rapid onset of action, long-lasting effect and good tolerability. However, like any medicine, avanafil should be used only as prescribed by a doctor, taking into account all contraindications and possible interactions.
 
 
 

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